Comparison of Topoisomerase I Inhibition, DNA Damage, and Cytotoxicity of Camptothecin Derivatives Presently in Clinical Trials
作者： A. Tanizawa , A. Fujimori , Y. Fujimori , Y. Pommier
关键词: Biology 、 Topotecan 、 Camptothecin 、 Cytotoxicity 、 Topoisomerase 、 In vitro 、 Mechanism of action 、 Topoisomerase-I Inhibitor 、 DNA damage 、 Biochemistry
摘要: Background: Camptothecins belong to a group of anticancer agents with a unique mechanism of action: poisoning of eukaryotic DNA topoisomerase I. Two camptothecin …
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