High-risk human papillomavirus prevalence in self-collected cervicovaginal specimens from human immunodeficiency virus (HIV)-negative women and women living with HIV living in Botswana.

摘要: Background The prevalence of high-risk human papillomavirus (hrHPV) is poorly described overall and in women living with HIV (WLWH) HIV-negative Botswana, a high cervical cancer-burden country. We conducted pilot study self-collection HPV testing for screening, from which data on was available. Methods From five health facilities the Kweneng East District, 1,022 aged 30–49 years were enrolled to self-collect their cervicovaginal specimen hrHPV by Xpert Test (Cepheid, Sunnyvale, CA, USA). Crude age group-adjusted status calculated, relationship risk groups HPV16>HPV18/45>other types) presence severity visible lesions. Results Of enrolled, 1,019 (99.7%), 570 WLWH 449 women, had results. prevalences 25.2% (95%CI = 21.2–29.4%) 40.4% 36.3–44.5%) WLWH. Age 23.7% 19.9–27.9%) 41.3% 37.2–45.4%) HPV16 (p<0.001), HPV18/45 HPV31/33/35/52/58 HPV39/56/66/68 (p 0.011) greater among than women. Riskier more likely have abnormalities (ptrend 0.004) not eligible cryotherapy 0.030). Conclusions hrHPV infection common all extent counterparts. Strategies triage hrHPV-positive will be needed avoid over-treating many benign infections.