Bacterial infection is independently associated with failure to control bleeding in cirrhotic patients with gastrointestinal hemorrhage

摘要: Bacterial infection is frequently diagnosed in cirrhotic patients with variceal hemorrhage. The aim of this study was to assess the incidence failure control bleeding during first 5 days after episode relation diagnosis bacterial and use antibiotics. One hundred seventy-seven consecutive admissions for gastrointestinal 151 were evaluated prospectively. From them, 163 137 included main analysis. Bleeding managed a standardized protocol using octreotide or terlipressin sclerotherapy band ligation active at endoscopy. end points defined as Baveno guidelines related transfusion requirement fresh hematemesis 6 hours from time zero. screening consisted chest radiograph blood, urine, ascitic fluid cultures. Active reported endoscopy 86 (53%). Failure occurred 76 patient (47%). Empirical antibiotic treatment used 113 (69%), whereas 81% them (91 admissions, 56%) 102 infections documented. Multivariate analysis showed that proven (P < .0001) .003) well .001) Child-Pugh score .02) independent prognostic factors bleeding. results remained unchanged when all any source multivariate associated needs be planning clinical trials.