Multiple Organ Failure Syndrome in the 1990s

摘要: Objective. —This review of the systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction (MODS) provides an overview a common but complex problem found in critically ill patients. It emphasizes definitions, clinical patterns, metabolic responses, pathophysiological changes. A brief discussion treatment concepts is also included. Data Sources. —Data for this were gathered from peer-reviewed journals, articles by experts SIRS/MODS, selections reference volumes written on SIRS/MODS. Study Selection. —Reference chosen basis quality research. Peer-reviewed journals given primary consideration. Those cited felt to be essential any Extraction. —Where possible, randomized, controlled, prospective studies reviewed conclusions used Conclusion. —Our ability care patients has led new problem, SIRS eventually MODS, which may become progressive failure death. Unfortunately, these conditions are extremely frequent carry high mortality rates. Increased oxygen consumption demands highlight physiological response. The typical responses characterized hyperglycemia accelerated protein catabolism. Unrecognized perfusion deficits, uncontrolled septic focus, persistent source inflammation, or injured tissue commonly present with SIRS/MODS should corrected. Restoration transport support important components treatment. cause not fully understood, mediators stimulated macrophages likely areas where well focused. (JAMA. 1994;271:226-233)