Translating genomics into mechanisms of disease: Osteoarthritis.

摘要: Osteoarthritis (OA) is the most common age-related arthritic disorder and characterized by aberrant extracellular matrix (ECM) content surface disruptions that range from fibrillation, clefting delamination, leading to articular erosion. Worldwide, over 20% of population affected with OA 80% these patients have limitations in movement, whereas 25% experience inhibition major daily activities life. disabling disease; nevertheless, no disease-modifying treatment available except for expensive total joint replacement surgery at end-stage disease. Lack insight into underlying pathophysiological mechanisms has considerably contributed inability scientific community develop drugs. To overcome this critical barrier, focus should be on translation identified robust gene deviations towards biological mechanisms.