Efficacy and tolerability of policosanol in hypercholesterolemic postmenopausal women.

摘要: This randomized, double-blind, multicenter placebo-controlled study was conducted to investigate the efficacy and tolerability of policosanol, a cholesterol-lowering drug purified from sugar cane wax, in women who had experienced menopause showed elevated serum total cholesterol low density lipoprotein (LDL)-cholesterol levels despite 6-week standard lipid-lowering diet. Thus, 56 eligible patients were randomized receive placebo or policosanol 5 mg/day for 8 weeks dose doubled 10 during next weeks. Policosanol (5 mg/day) significantly decreased LDL-cholesterol (17.3% 26.7%, respectively), (12.9% 19.5%) as well ratios high-density (HDL)-cholesterol (17.2% 26.5%) HDL-cholesterol (16.3% 21.0%) compared with baseline placebo. raised by 7.4% at completion. No significant changes occurred lipid profile group. The safe tolerated. drug-related adverse effects observed. None administered but three those withdrew trial because effects: one due serious hypertensive status, an allergic reaction (pruritus plus skin rash) gastrointestinal disturbances (nauseas vomiting). Eleven reported 24 six seven (p < 0.05). In addition, five (17.9%) 13 (46.4%) 0.05) improvements habitual symptoms health perception study. conclusion, effective tolerated hypercholesterolemic postmenopausal women, showing additional benefits patients.