Comparison of the effects of policosanol and atorvastatin on postmenopausal women with type II hypercholesterolemia
作者： José Illnait , Gladys Castaño , Lilia Fernández , Melbis Mesa , Sarahí Mendoza
DOI:
关键词: Atorvastatin 、 Tolerability 、 Postmenopausal women 、 Endocrinology 、 Internal medicine 、 Gastroenterology 、 Transaminase 、 Policosanol 、 Dyslipidemia 、 Rash 、 Elevated serum 、 Medicine
摘要: Postmenopausal women show elevated serum low-density lipoprotein-cholesterol (LDL-C), total cholesterol (TC), and low high-density (HDL-C) compared with premenopausal women, to control their dyslipidemia means lower LDL-C levels. Policosanol (5 20 mg/d) is an effective cholesterol-lowering agent, atorvastatin (10 - 80 one of the most efficacious statins. This randomized, single-blinded study efficacy tolerability policosanol in postmenopausal type II hypercholesterolemia. After a baseline diet step, 60 patients were randomized or 10-mg/d for 8 weeks. significantly (p < 0.000 01) lowered (32.8 39.7 %, respectively), TC (23.6 29.1 %) 0.001) TG (11.3 17.6 %), whereas increased 1 p HDL-C 9.9 respectively). Atorvastatin was more than polico- sanol reduce LDL -C, 0.05) TG. Both drugs well tolerated. 0.01), while transaminase creatinphosphokinase Three patients, all from atrovastatin, withdrew trial due adverse experiences (AE). The AE (five patients) frequent (one patient). policosanol-patient reported headache, referred rash (3), tachycardia (1),
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