Personalized cancer therapy using a patient-derived tumor tissue xenograft model: a translational field worthy of exploring further?
作者： Ketao Jin , Kuifeng He , Guangliang Li , Lisong Teng
DOI: 10.2217/PME.10.48
关键词:
摘要: It has long been observed that interpatient variability in response to anticancer drugs is associated with different outcomes. Oncologists continually hold the desire of matching right therapeutic regimen cancer patient, which termed ‘personalized therapy’. Rapid advances genetics, genomics and related technologies are promising a new era personalized therapy based on individual molecular biomarkers. However, these predictors tumor far from perfect. Because inherent limitations current approaches for prediction, need techniques predict urgent. Using patient-derived human tissue (PDTT) xenograft model might be an ideal candidate method choose. This article provides overview achievements genetic, genomic proteomic markers therapy, further di...
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