Erythrocyte enzyme activities in myelodysplastic syndromes: elevated pyruvate kinase activity.
作者： Kenzaburo Tani , Hisaichi Fujii , Keisuke Takahashi , Hideki Kodo , Shigetaka Asano
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摘要: The erythrocyte enzyme activities in twenty-six cases of myelodysplastic syndromes were determined. There remarkably abnormal levels seven cases; namely, four showed increased hexokinase activity, three pyruvate kinase and two adenosine deaminase activity. Among these, one case with elevated activity the novel expression M2-type addition to R-type normally found erythrocytes. Southern blotting peripheral leucocyte DNA revealed only an amplified PK-LR genome, which derived from chromosomal abnormality a 1;7 translocation. mechanism responsible for switching during erythroid maturation was considered be partially disrupted this case.
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