The farnesoid X receptor induces very low density lipoprotein receptor gene expression
作者： Audrey Sirvent , Thierry Claudel , Geneviève Martin , John Brozek , Vladimir Kosykh
DOI: 10.1016/J.FEBSLET.2004.04.026
关键词:
摘要: The farnesoid X receptor (FXR) is a nuclear activated by bile acids (BAs). In response to ligand-binding, FXR regulates many genes involved in BA, lipid, and lipoprotein metabolism. To identify new target genes, microarray technology was used profile total RNA extracted from HepG2 cells treated with the natural agonist chenodeoxycholic acid (CDCA). Interestingly, significant increase of transcript level very low density (VLDLR) observed. Our data, resulting selective activation, silencing FXR-deficient mice, clearly demonstrate that BAs up-regulate VLDLR levels via FXR-dependent mechanism vitro human vivo mouse liver cells.
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