Tumourigenesis associated with the p53 tumour suppressor gene.

摘要: The p53 gene is contained within 16-20 kb of cellular DNA located on the short arm human chromosome 17 at position 17p13.1. This encodes a 393-amino-acid nuclear phosphoprotein involved in regulation cell proliferation. Current evidence suggests that loss normal function associated with transformation vitro and development neoplasms vivo. More than 50% malignancies epithelial, mesenchymal, haematopoietic, lymphoid, central nervous system origin analysed thus far, were shown to contain an altered gene. oncoproteins derived from several tumour viruses, including SV40 large T antigen, adenovirus E1B protein papillomavirus E6 protein, as well specific products, e.g. murine double minute-2 (MDM2), found bind wild-type presumably lead inactivation this product. Therefore, suppressor currently regarded almost universal step cancers. current data p53-associated tumourigenesis are briefly discussed minireview.