p53: functions, mutations and sarcomas

摘要: The p53 gene is the most commonly altered in a multitude of human cancers. alterations can be acquired somatically or transmitted through germ-line. Bone and soft tissue sarcomas are frequently found to have abnormalities mdm-2 genes. In sarcoma, amplification binding its oncogene product wild-type protein functionally inactivates normal p53-regulated growth. Inherited mutations associated with rare Li-Fraumeni familial cancer syndrome. Various tumor types arise these families, bone tissues carcinoma breast being observed. Transgenic mice highly expressed mutated higher incidence tumors, including predominantly osteosarcomas sarcomas. close similarity syndrome, homozygously p53-null (transgenic carrying two non-functional allele) developmentally how...