The usefulness of high pre-operative levels of serum type I collagen bone markers for the prediction of changes in bone mineral density after parathyroidectomy.

摘要: Background: Amino-terminal procollagen propeptide of type I collagen (P1 NP) and cross-linked C-terminal telopeptide (βCTX) are two the more sensitive bone markers for reflecting monitoring patients with an increased turnover as observed in primary hyperparathyroidism (PHPT) patients. Aim: The present study was performed to evaluate trend one year after parathyroidectomy (PTX) examine relationships between serum P1 NP βCTX levels mineral density (BMD) change PTX PHPT Spanish Materials methods: Fifty-three were enroled followed by measuring lumbar BMD, t-score, z-score, PTH, calcium, phosphorus, βCTX. Results: Pre-surgery concentrations both elevated NP: 90.71 ±5.03; βCTX: 1.52±0.44). A significant decrease mean post-operative (p<0.0001). Levels t-score z-score at spine relatively low (BMD: 0.75±0.16; −0.90±0.23; −2.51 ±0.32); a increase these three parameters. P1NP correlated BMD r=0.79, p=0.016; r=0.89, p=0.003). Conclusions: found. Serum potently related changes over PTX. measurement would be useful predict long-term