Genetic and environmental contributions to cannabis dependence in a national young adult twin sample.

摘要: Background. This paper examines genetic and environmental contributions to risk of cannabis dependence. Method. Symptoms dependence measures social, family individual factors were assessed in a sample 6265 young adult male female Australian twins born 1964-1971. Results. common: 11(.)0% (15(.)1% men 7(.)8% women) reported two or more symptoms Correlates included educational attainment, exposure parental conflict, sexual abuse, major depression, social anxiety childhood conduct disorder. However, even after control for the effects these factors, there was evidence significant on Standard modelling indicated that 44(.)7% (95% CI = 15-72(.)2) variance liability could be accounted by 20(.)1% (95 0-43(.)6) attributed shared environment 35(.)3% 26(.)4-45(.)7) non-shared factors. while no gender differences magnitude influences, model which assumed both influences risks among but women provided an equally good fit data. Conclusions. There consistent are important determinants men. it remains uncertain whether women.