Dynorphin: potent analgesic effect in spinal cord of the rat.
作者： Ji-Sheng Han , Cui-Wei Xie
DOI: 10.1016/0024-3205(82)90209-0
关键词:
摘要: Abstract Evidence is presented to show a strong and long-lasting analgesic effect after injection of dynorphin into the subarachnoid space spinal cord rat. Calculating on molar basis was 6–10 times more potent than morphine 65–100 morphiceptin, specific mu receptor agonist. Dynorphin analgesia completely reversed by intrathecal anti-dynorphin IgG partially naloxone. Acute tolerance did not affect occurence analgesia. from different lines approach suggest that may bind with kappa receptors in exert its effect.
elsevier.com
sci-hub.se 参考文章(10)
J.Michael Walker, Richard J. Katz, Huda Akil, Behavioral effects of dynorphin1–13 in the mouse and rat: Initial observations Peptides. ,vol. 1, pp. 341- 345 ,(1980) , 10.1016/0196-9781(80)90012-1
Ernest P. Noble, Richard J. Wurtman, Julius Axelrod, A simple and rapid method for injecting H3-norepinephrine into the lateral ventricle of the rat brain Life Sciences. ,vol. 6, pp. 281- 291 ,(1967) , 10.1016/0024-3205(67)90157-9
Paul L. Wood, A. Rackham, J. Richard, Spinal analgesia: comparison of the mu agonist morphine and the kappa agonist ethylketazocine. Life Sciences. ,vol. 28, pp. 2119- 2125 ,(1981) , 10.1016/0024-3205(81)90618-4
C Chavkin, I. James, A Goldstein, Dynorphin is a specific endogenous ligand of the kappa opioid receptor. Science. ,vol. 215, pp. 413- 415 ,(1982) , 10.1126/SCIENCE.6120570
M.J. Millan, Y.F. Tsang, R. Przewłocki, V. Höllt, A. Herz, The influence of foot-shock stress upon brain, pituitary and spinal cord pools of immunoreactive dynorphin in rats Neuroscience Letters. ,vol. 24, pp. 75- 79 ,(1981) , 10.1016/0304-3940(81)90362-1
Tony L. Yaksh, Thomas A. Rudy, Chronic catheterization of the spinal subarachnoid space. Physiology & Behavior. ,vol. 17, pp. 1031- 1036 ,(1976) , 10.1016/0031-9384(76)90029-9
Michael Wüster, Rüdiger Schulz, Albert Herz, Opiate activity and receptor selectivity of dynorphin1-13 and related peptides. Neuroscience Letters. ,vol. 20, pp. 79- 83 ,(1980) , 10.1016/0304-3940(80)90237-2
Howard J. Friedman, Ming-Feng Jen, Jaw Kang Chang, Nancy M. Lee, Horace H. Loh, Dynorphin: A possible modulatory peptide on morphine or β-endorphin analgesia in mouse European Journal of Pharmacology. ,vol. 69, pp. 357- 360 ,(1981) , 10.1016/0014-2999(81)90483-0
K. Chang, A Lillian, E Hazum, P Cuatrecasas, J. Chang, Morphiceptin (NH4-tyr-pro-phe-pro-COHN2): a potent and specific agonist for morphine (mu) receptors Science. ,vol. 212, pp. 75- 77 ,(1981) , 10.1126/SCIENCE.6259732
H. Takagi, Advances in Endogenous and Exogenous Opioids ,(1982)