Methods of preventing immune-mediated abortion by inhibiting a CD28-mediated costimulatory signal

作者: Srinivas Maganti , Vincent Ling , Gary S. Gray , James C. Keith

DOI:

关键词:

摘要: Method of inhibiting and diagnosing spontaneous abortion in a subject are provided. The methods based, inter alia, on the administration an agent that inhibits costimulatory signal T cell such is inhibited. also based levels adhesion molecules, inflammatory cytokines, immune surface molecules which altered abortion.

参考文章(44)
Uzi Gafter, Benjamin Sredni, Jacob Segal, Yona Kalechman, Suppressed cell-mediated immunity and monocyte and natural killer cell activity following allogeneic immunization of women with spontaneous recurrent abortion Journal of Clinical Immunology. ,vol. 17, pp. 408- 419 ,(1997) , 10.1023/A:1027372409361
P Matzinger, E A Bonney, THE MATERNAL IMMUNE SYSTEM'S INTERACTION WITH CIRCULATING FETAL CELLS Journal of Immunology. ,vol. 158, pp. 40- 47 ,(1997)
N S Ostlie, M A Ewoldsen, C M Warner, Killing of mouse blastocyst stage embryos by cytotoxic T lymphocytes directed to major histocompatibility complex antigens. Journal of Immunology. ,vol. 138, pp. 2764- 2770 ,(1987)
Jurgen Bajorath, Peter S. Linsley, Robert Peach, William Brady, Jeffrey A. Ledbetter, CTLA4/CD28Ig hybrid fusion proteins and uses thereof Official Gazette of the United States Patent and Trademark Office Patents. ,(1994)
Andreas Hutloff, Anna M. Dittrich, Katja C. Beier, Barbara Eljaschewitsch, Regine Kraft, Ionnis Anagnostopoulos, Richard A. Kroczek, ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28 Nature. ,vol. 397, pp. 263- 266 ,(1999) , 10.1038/16717
S.M. Albelda, P.J. Newman, H.M. Shen, T. Trask, H.S. Baldwin, A. Chung, C. Mickanin, N.E. Kirschbaum, H.C. Yan, H.M. DeLisser, Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development Development. ,vol. 120, pp. 2539- 2553 ,(1994) , 10.1242/DEV.120.9.2539
C H June, G S Gray, F T Hakim, R Cepeda, R Abe, Acute graft-versus-host reaction can be aborted by blockade of costimulatory molecules. Journal of Immunology. ,vol. 155, pp. 1757- 1766 ,(1995)
S. Romagnani, P. Parronchi, M.M. D’Elios, P. Romagnani, F. Annunziato, M-P. Piccinni, R. Manetti, S. Sampognaro, C. Mavilia, M. De Carli, E. Maggi, G-F. Del Prete, An update on human Th1 and Th2 cells International Archives of Allergy and Immunology. ,vol. 113, pp. 153- 156 ,(1997) , 10.1159/000237532