Macrosomia in infants of insulin-dependent diabetic mothers

摘要: The purpose of the present study was to evaluate factors affecting rate macrosomia and related complications in a population infants insulin-dependent diabetic mothers. following were hypothesized be predisposing macrosomia: increased maternal weight gain during gestation, number births until infant No. 3, white race, age, poor glycemic control from 20th week insulin dose. Advance White classification duration diabetes predicted inversely related. In addition, predispose selected adverse perinatal outcomes including premature labor, birth asphyxia, injury, hypoglycemia, polycythemia, respiratory distress syndrome. From 1978 1986, 127 pregnancies prospectively studied, 86 total women entered prior 10 weeks9 41 after gestation. Patients monitored blood glucose at least twice daily with achieved by "split-dosage" regimens insulin. Glycohemoglobin measured monthly. Pregnancy dating based on date last menstrual period Ballard score birth. Macrosomia defined as greater than 90th percentile intrauterine growth curves Lubchenco. Of babies born mothers diabetes, 43% large for gestational age 57% appropriate age. Maternal an being included glycohemoglobin measurement time delivery (large = 8.4% ± 0.3%, 7.6% 0.2%, P