In vivo veritas : The search for TB drug targets goes live

摘要: The term 'microbial persistence' describes a phenomenon whereby microorganisms which are drug-susceptible when tested outside the body nevertheless capable of surviving within despite intensive therapy with appropriate antimicrobial drug. In clinical practice this obviously has to do post-treatment 'carrier state' and relapse. short, it is responsible for our inability eradicate an infection from person or community by use drugs. - Walsh McDermott, Yale Journal Biology Medicine 30, 257 (1958).