Hepatotoxin-induced hypertaurinuria: a proton NMR study
作者： Susan M. Sanins , Jeremy K. Nicholson , Cliff Elcombe , John A. Timbrell
DOI: 10.1007/BF01973464
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摘要: The urinary excretion of taurine by rats after dosing with various hepatotoxins has been investigated by1H NMR spectroscopy. After single hepatotoxic doses hydrazine, carbon tetrachloride, 1-naphthylisothiocyanate, or thioacetamide there was biochemical and histopathological evidence hepatic damage. Proton spectroscopy the urine collected for 24 h from these animals revealed a marked elevation in (control 11.9 μmole/h/kg) (42.2 μmole/h/kg), tetrachloride (52.5 gmmole/ h/kg), 1-naphthyl-isothiocyanate (80.4 hydrazine (52.9 μmmole/h/kg). allyl alcohol administration no increase (7.5 μmol/h/kg). dose related. High resolution proton spectroscopic analysis also resonances several metabolites an N-acetylcysteine conjugate alcohol, acetamide as metabolite respective compounds. Changes endogenous substances that may be related to pathological events were detected, such decrease 2-oxoglutarate citrate both administration. results confirm is powerful analytical tool evaluation study toxic substances. Furthermore, measurement provide non-invasive indicator acute damage certain classes hepatotoxins.
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