Inflammatory Markers and Cardiovascular Risk in Healthy Polish Women across the Menopausal Transition

摘要: Cessation of ovarian function and sex hormone deficiency are associated with metabolic disorders that increase the risk cardiovascular disease in women after menopause (1)(2). Changes steroids may influence inflammatory processes lipid metabolism during menopausal transition. The status estrogen at early perimenopause is similar to premenopause, whereas decreased estradiol more likely late (3–11 months amenorrhea) (3). Several studies have demonstrated concentrations, body weight, blood pressure, insulin resistance endothelial impaired (4)(5)(6)(7). Recent data indicate chronic inflammation lead atherosclerosis healthy populations. It has been suggested systemic markers such as C-reactive protein (CRP) interleukin-6 (IL-6) important predictors risk, measurement their concentrations predictive value traditional screening (8)(9). CRP assayed by high-sensitivity methods enables evaluation low-grade atherosclerosis. Rifai et al. (10)(11) recently proposed algorithms for prediction using total cholesterol/HDL-cholesterol (TC/HDL-C) or LDL-cholesterol (LDL-C) values. We investigated relationship between hormonal assessed laboratory variables Our study included 80 perimenopausal [PERI; mean (SD) age, 47 (3) years] 78 postmenopausal [POST; age (SD), 53 (4) nonsmoking women. PERI had irregular menses previous 12 least one climacteric symptom (hot flashes, night sweats, vaginal dryness, sleeping difficulties, mood swings). POST were divided into 2 groups: 40 early-POST (1–5 years without menses) 38 late-POST (6–10 menses). None …