Fischer 344 rats are the same weight but are fatter than S5B P1Ras rats fed a high fat diet

摘要: Abstract Inbred strains of rats are excellent models to study genetics diet-induced obesity. Six weanling from each 4 strains, S5BP1Ras (S5B), Fischer 344, Osborne-Mendel (OM) and Sprague-Dawley (SD) were fed a high-fat diet for 10 weeks until sacrifice. Body wt length, food intake, fat depot muscle weights, body composition serum triglycerides, cholesterol, glucose, insulin, insulin-like growth factor-I (IGF-I) concentrations determined. weights similar S5B 344 both weighed significantly less than OM or SD rats. also consumed However, utilized more energy the other rather storing it as fat. In rats, ranged 25 31% whereas in was 16 ± 1%. Differences significant. Individual white depots 150 400% protein, expressed g/100g carcass, 30% greater while two intermediate. The same true mass. high hyperinsulinemic mean insulin normal had lower glucose but there no strain differences. Serum triglyceride, cholesterol IGF-I strains.