Effect of High Fat Diets on the Thermogenic Activity of Brown Adipose Tissue in Cold-Acclimated Mice
作者： Stewart W. Mercer , Paul Trayhurn
关键词:
摘要: The effects of feeding high fat diets on thermogenesis in brown adipose tissue has been investigated cold-acclimated mice. Two differing fatty acid composition were used, one which was based corn oil and the other beef tallow. After 3 weeks there little difference weight, protein content cytochrome oxidase activity (interscapular plus subscapular) mice fed from those given low stock diet. However, showed marked increases mitochondrial GDP binding respiration, consistent with an augmentation proton conductance pathway. This increase mitochondria occurred without any elevation digestible energy intake, is therefore not a response to overfeeding. It concluded that pathway can be modulated by level dietary triglyceride independently intake. We suggest effect may relate suppressive lipid synthesis tissue.
oup.com
nutrition.org
researchgate.net 参考文章(33)
David G. NICHOLLS, Hamster Brown-Adipose-Tissue Mitochondria FEBS Journal. ,vol. 49, pp. 573- 583 ,(1974) , 10.1111/J.1432-1033.1974.TB03861.X
Barbara Cannon, Olov Lindberg, [8] Mitochondria from brown adipose tissue: Isolation and properties Methods in Enzymology. ,vol. 55, pp. 65- 78 ,(1979) , 10.1016/0076-6879(79)55010-1
H. Kasper, H. Thiel, M. Ehl, Response of body weight to a low carbohydrate, high fat diet in normal and obese subjects The American Journal of Clinical Nutrition. ,vol. 26, pp. 197- 204 ,(1973) , 10.1093/AJCN/26.2.197
Himms-Hagen J, Obesity may be due to a malfunctioning of brown fat Canadian Medical Association Journal. ,vol. 121, pp. 1361- 1364 ,(1979)
Nancy J. Rothwell, Michael J. Stock, Robert S. Tyzbir, Energy Balance and Mitochondrial Function in Liver and Brown Fat of Rats Fed “Cafeteria” Diets of Varying Protein Content Journal of Nutrition. ,vol. 112, pp. 1663- 1672 ,(1982) , 10.1093/JN/112.9.1663
Margaret Ashwell, Graham Jennings, Denis Richard, Dorothy M. Stirling, Paul Trayhurn, Effect of acclimation temperature on the concentration of the mitochondrial ‘uncoupling’ protein measured by radioimmunoassay in mouse brown adipose tissue FEBS Letters. ,vol. 161, pp. 108- 112 ,(1983) , 10.1016/0014-5793(83)80740-6
David O. Foster, M. Lorraine Frydman, Nonshivering thermogenesis in the rat. II. Measurements of blood flow with microspheres point to brown adipose tissue as the dominant site of the calorigenesis induced by noradrenaline. Canadian Journal of Physiology and Pharmacology. ,vol. 56, pp. 110- 122 ,(1978) , 10.1139/Y78-015
Nancy J. Rothwell, Michael J. Stock, A role for brown adipose tissue in diet-induced thermogenesis Nature. ,vol. 281, pp. 31- 35 ,(1979) , 10.1038/281031A0
David G. Nicholls, Brown adipose tissue mitochondria Biochimica et Biophysica Acta. ,vol. 549, pp. 1- 29 ,(1979) , 10.1016/0304-4173(79)90016-8
M. Desautels, G. Zaror-Behrens, J. Himms-Hagen, Increased purine nucleotide binding, altered polypeptide composition, and thermogenesis in brown adipose tissue mitochondria of cold-acclimated rats Biochemistry and Cell Biology. ,vol. 56, pp. 378- 383 ,(1978) , 10.1139/O78-060