Brown adipose tissue metabolism in ob/ob mice: effects of a high-fat diet and adrenalectomy

摘要: Adrenalectomy prevents development of obesity in ob/ob mice fed high-carbohydrate stock diets partly by stimulating the low thermogenic capacity their brown adipose tissue (BAT). Adrenalectomy, however, fails to prevent a high-fat diet. Effects adrenalectomy on BAT metabolism diet were thus examined. developed gross despite normal metabolism, as assessed rates norepinephrine turnover BAT, GDP binding mitochondria, and GDP-inhibitable, chloride-induced mitochondrial swelling. failed arrest or influence Development is not associated with adrenal secretions, it diets.