GT repeat polymorphism in the 5′ flanking region of the human growth hormone receptor gene
作者： S. Hadjiyannakis , H. Zheng , G.N. Hendy , C.G. Goodyer
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摘要: Abstract A polymorphic GT dinucleotide repeat sequence has been identified in the 5′ flanking region of human growth hormone receptor ( hGHR ) gene on chromosome 5p13.1-p12, within promoter V9 5′UTR exon. Thirteen alleles have 50 non-related individuals, with an observed heterozygosity 52%. The major allele contains 24 repeats, although a range 19–32 repeats observed. Codominant segregation was demonstrated five two-generation and two three-generation families. This marker may be useful analysing role pre- postnatal disorders.
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