Targeting HIV attachment and entry for therapy.

摘要: Publisher Summary Over the past two decades, tremendous strides have been made in development of potent antiviral drugs to treat human immunodeficiency virus (HIV) infection. Recently, attention has focused on a new class compounds known as entry inhibitors. These agents act at early steps viral life cycle protect target cells from HIV This chapter provides background and rationale for targeting different stages process an overview that are being developed treatment prevention The first specific interaction with cell involves binding gp120 envelope spike CD4 receptor surface cell. Inhibition this initial step infection can be achieved by either protein or alternatively receptor. Agents both proteins identified found activity.