Associations of five polymorphisms in the CD44 gene with cancer susceptibility in Asians.

摘要: CD44 polymorphisms have been previously associated with cancer risk. However, the results between independent studies were inconsistent. Here, a meta-analysis was performed to systematically evaluate associations and susceptibility. A comprehensive literature search conducted in PubMed, Embase, Web of Science databases through August 10, 2016 yielded 11 eligible publications consisting 5,788 patients 5,852 controls. Overall, odds ratios (OR) calculated 95% confidence intervals (CI) identified significant association polymorphism rs13347 susceptibility under all genetic models. Additionally, minor allele rs11821102 decreased contrast, dominant, heterozygous models, while no for rs10836347, rs713330, or rs1425802. Subgroup analysis by ethnicity revealed significantly Chinese but not Indians. Linkage disequilibrium (LD) different varied across diverse ethnic populations. In conclusion, indicate that acts as risk factor cancer, especially Chinese, may be cancer. Nevertheless, further on larger population covering ethnicities are warranted.