Molecular biology of brain metastasis.

摘要: Metastasis to the central nervous system (CNS) remains a major cause of morbidity and mortality in patients with systemic cancer. As length survival cancer improves, thanks multimodality therapies, focusing on metastases CNS becomes paramount importance. Unique interactions between brain’s micro-environment, blood-brain barrier, tumor cells are hypothesized promote distinct molecular features that may require tailored therapeutic approaches. This review will focus pathophysiology, epigenetics, immunobiology brain order understand metastatic cascade. Cancer escape primary tumor, intravasate into blood vessels, survive hematogenous dissemination CNS, arrest capillaries, extravasate, proliferate, develop angiogenic abilities establish metastases. Molecular biology, genetics, epigenetics rapidly expanding, enabling us advance our knowledge underlying mechanisms involved. Research approaches using cell lines preferentially metastasize vivo vitro tissue-based studies unfold new leads disease. It is important identify pathways cascade target investigation development more effective therapies research directions.