Incidence of Metachronous Testicular Cancer in Patients With Extragonadal Germ Cell Tumors

摘要: Incidence of metachronous testicular cancer in patients with extragonadal germ cell tumours. Background: The frequency subsequent (referred to as cancer) men who have had previous is relatively high. rate tumors (EGCTs), however, largely unknown. We conducted a retrospective study EGCT determine the incidence, cumulative risk, and specific risk factors for cancers. Methods: A standardized questionnaire about patient characteristics, extent disease, any second malignancies, treatments received was completed 635 EGCTs identified from medical records 11 centers Europe United States 1975 through 1996. Comparisons age group- data Saarland, Germany, population-based registry were used calculate incidence ratio (SIR). Kaplan-Meier method analyze survival risk. All statistical tests two-sided. Results: Sixteen (4.1%) developed cancers, median time between diagnoses 60 months (range, 14-102 months). developing cancers statistically significantly increased (observed = 16; expected 0.26; SIR 62; 95% confidence interval [CI] 36 99) subsets mediastinal location (SIR 31; CI 8 59), retroperitoneal 100; 54 172), nonseminomatous histology 75; 43 123). 10 years after diagnosis 10.3% (95% 4.9% 15.6%) higher among (14.3%; 6.7% 21.9%) (14.2%; 5.6% 22.8%) than seminomatous (1.4%; 0.0% 4.2%) (6.2%; 0.1% 12.2%). Conclusions: Patients EGCTs, particularly those or tumors, but also primary are at an cancer.