Variability and exposure classification of urinary phenol and paraben metabolite concentrations in reproductive-aged women

摘要: Abstract Background Human exposure to phenols and parabens is widespread. Within-person variability of urinary concentrations in healthy women not well characterized. Objectives To characterize the phenol paraben across two months evaluate ability a single spot urine sample exposure. Methods 143 provided 509 samples collected study (3–5 samples/woman). We measured 8 phenols: bisphenol A (BPA), benzophenone-3 (BP-3), benzophenone-1 (BP-1), 2,4-dichlorophenol (2,4-DCP), 2,5-dichlorophenol (2,5-DCP), 2,4,5-trichlorophenol (2,4,5-TCP), 2,4,6-trichlorophenol (2,4,6-TCP), triclosan (TCS); their metabolites (benzyl (BzP), butyl (BuP), ethyl (EtP), heptyl (HeP), methyl (MeP), propyl (PrP), 4-hydroxybenzoic acid (4-HB), 3,4-dihydroxybenzoic (3,4-DHB)). Biomarker was characterized using intraclass correlation coefficient (ICC) surrogate category analyses were conducted. Results ICCs ranged from very low for BPA (0.04) moderate BP-3, BP-1, TCS, BzP, MeP (0.66, 0.58, 0.55, 0.54, 0.62, respectively). Surrogate suggested that 2,4-DCP, BuP, PrP may be by (sensitivity range 0.76–0.86) but additional necessary BPA, HeP, 4-HB, 3,4-DHB 0.47–0.61). Conclusions Urinary metabolite variable degree reliability differed specific biomarker. small number sufficiently typical PrP; biospecimens other compounds, including BPA.