Analytical method for the determination and a survey of parabens and their derivatives in pharmaceuticals.
作者： Cristina Moreta , María-Teresa Tena , Kurunthachalam Kannan
DOI: 10.1016/J.ENVRES.2015.07.014
关键词:
摘要: Exposure of humans to parabens is a concern due the estrogenic activity these compounds. Parabens are widely used as preservatives in some personal care products, foodstuffs and pharmaceuticals owing their low cost, high water solubility broad spectrum antimicrobial properties. Despite this, little known on occurrence pharmaceutical products. In this study, method based solid-liquid or liquid-liquid extraction (SLE LLE), performance liquid chromatography (HPLC) coupled with triple quadrupole tandem mass spectrometry (QqQ MS/MS) was developed for determination six most frequently four paraben derivatives (methyl- ethyl-protocatechuates, mono- di-hydroxybenzoic acids) pharmaceuticals. A sample-purification step involving solid phase (SPE) optimized analysis lipid-rich To our knowledge, first comprehensive report The applied 128 liquid/syrup, cream, solid, prescription over-the counter (OTC) drugs collected from USA few other countries Europe Asia. Although majority analyzed study did not contain parabens, concentrations 2 mg/g were found drugs. Methyl- propyl- detected 4-Hydroxybenzoic acid major metabolite
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