Post-translational modification of p53.

摘要: The p53 tumor suppressor protein is extensively post-translationally modified, mostly by phosphorylation. phosphorylation sites are clustered into two distinct domains within the polypeptide and kinases phosphatases which modify many of these have been identified. In addition, signaling pathways modulate state p53, leading perhaps to changes in its activity, being actively investigated. Similarly, transforming proteins DNA viruses may therefore be useful tools for probing regulatory mechanisms. Given very potent effects on cell growth extent this protein, well controlled tightly coordinately more than one mechanism.