A phase I pharmacokinetic (PK) and molecular pharmacodynamic (PD) study of the combination of two anti-EGFR therapies, the monoclonal antibody (MAb) cetuximab (C) and the tyrosine kinase inhibitor (TKI) gefitinib (G), in patients (pts) with advanced colorectal (CRC), head and neck (HNC) and non-small cell lung cancer (NSCLC)

作者: J. Baselga , P. Schöffski , F. Rojo , H. Dumez , F. J. Ramos

DOI: 10.1200/JCO.2006.24.18_SUPPL.3006

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摘要: 3006 Background: C and G are two anti-EGFR agents with different mechanisms of action. We had previously shown a synergistic effect combining the in preclinical models (Matar et al, Clin...

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