period-Regulated Feeding Behavior and TOR Signaling Modulate Survival of Infection.

摘要: Most metazoans undergo dynamic, circadian-regulated changes in behavior and physiology. Currently, it is unknown how impacts immunity against infection. Two broad categories of defense bacterial infection are resistance, control microbial growth, tolerance, the pathogenic effects Our study behaviorally arrhythmic Drosophila circadian period mutants identified a novel link between nutrient intake tolerance with B. cepacia, pathogen rising importance hospital-acquired infections. We found that wild-type animals stimulated by acute exposure to dietary glucose amino acids. Glucose-stimulated was induced feeding or direct injection; injections revealed a narrow window for glucose-stimulated tolerance. In contrast, acids only when ingested. investigated role known amino-acid-sensing pathway, TOR (Target Rapamycin) immunity. TORC1 regulated inhibition decreased as vertebrates. Surprisingly, inhibition of less well-characterized complex 2 (TORC2) dramatically increased survival, through both resistance mechanisms. This work suggests on day B. cepacia can make significant difference long-term survival. further demonstrate signaling mediates identify TORC2 potential therapeutic target increasing survival