Identification of Spen as a Crucial Factor for Xist Function through Forward Genetic Screening in Haploid Embryonic Stem Cells
作者： Asun Monfort , Giulio Di Minin , Andreas Postlmayr , Remo Freimann , Fabiana Arieti
DOI: 10.1016/J.CELREP.2015.06.067
关键词: Dosage compensation 、 Genetics 、 X chromosome 、 RNA-binding protein 、 XIST 、 Epigenetics 、 X-inactivation 、 Genetic screen 、 Chromatin 、 Biology
摘要: … of Spen. Using this strategy, we were successful in obtaining two independent ESC clones with Spen deletions in HATX3 ESCs and one clone with a homozygous deletion of Spen in …
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