Imprinted X inactivation maintained by a mouse Polycomb group gene.
作者： Jianbo Wang , Jesse Mager , Yijing Chen , Elizabeth Schneider , James C. Cross
DOI: 10.1038/NG574
关键词:
摘要: In mammals, dosage compensation of X-linked genes is achieved by the transcriptional silencing one X chromosome in female (reviewed ref. 1). This process, called inactivation, usually random embryo proper. marsupials and extra-embryonic region mouse, however, inactivation imprinted: paternal preferentially inactivated whereas maternal always active. Having more than active deleterious to development mouse2. Here we show that gene eed (embryonic ectoderm development)3,4, a member mouse Polycomb group (Pc-G) genes, required for primary secondary trophoblast giant cell embryos. Results from mice carrying paternally inherited green fluorescent protein (GFP) transgene implicate stable maintenance imprinted tissues. Based on recent finding Eed interacts with histone deacetylases, suggest this activity involves hypoacetylation
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