Promoter-specific hypoacetylation of X-inactivated genes
作者： S. L. Gilbert , P. A. Sharp
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摘要: The histone H4 acetylation status of the active X (Xa) and inactive (Xi) chromosomes was investigated at level individual genes. A moderate observed along lengths genes on both Xi Xa, regardless their inactivation status. However, this modified specifically in promoter regions. Transcriptionally showed elevated levels promoters Xa. In contrast, X-inactivated were markedly hypoacetylated, which coincided with methylation adjacent CG dinucleotides. This promoter-specific hypoacetylation may be a key component an machinery that operates
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