Discovery and profiling of a selective and efficacious syk inhibitor.
作者： Gebhard Thoma , Alexander B. Smith , Maurice J. van Eis , Eric Vangrevelinghe , Joachim Blanz
DOI: 10.1021/JM5018863
关键词:
摘要: We describe the discovery of selective and potent Syk inhibitor 11, which exhibited favorable PK profiles in rat dog was found to be active a collagen-induced arthritis model rats. Compound 11 selected for further profiling, but, unfortunately, GLP toxicological studies it showed liver findings dog. Nevertheless, could become valuable tool compound investigate rich biology vitro vivo.
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