Computational antioxidant capacity simulation assay of Garcinia kola (Heckel) seed extracts
作者： Olakunle Idowu Sunday , Ayodele Adeyemo Morenikeji , Abidemi Aderibigbe Segun , Idowu Omotayo Oluwabukola
关键词:
摘要: Polypharmacological activities of the biflavonoid fraction Garcinia kola seed justify its development as a nutraceutical, however, quality assurance active nutraceutical ingredient (ANI) requires conformance to appropriate standards composition and quality. It was hypothesized that variation in extraction protocols, previously reported for fraction, would lead extract potency. Computational antioxidant capacity simulation (CAOCS) assay G. extracts obtained by different protocols tested hypothesis, through incremental addition (250 100 µL) standard (AOX) solutions photometric titration. Preferred model fitting then statistically selected between mono- bi-exponential decay. Best - fit reaction constant (kptt) integrated into metric ranking (AOC) extracts. The AOC is molecular descriptor kinetics phenolic bond cleavage. Three AOX extracts, namely, ethyl acetate extract, kolaviron acetone were found vary composition, produced optimal values 1500/g, 1150/g, 1050/g respectively. Our findings demonstrated potency are critically dependent on solvent protocol, hence, consistent with hypothesis. CAOCS suitable analytical tool ensuring batch–to–batch sameness ANI prepared from seed. Key words: biflavonoids, ingredient, capacity, assurance.
sci-hub.se 参考文章(34)
Severine Derbre, Alexis Kaatio Toure, Pascale Richomme, Sylvie Morel, Anti-glycation agent comprising a garcinia kola extract or fraction ,(2013)
Sunday O. Idowu, Computational Antioxidant Capacity Simulation (CAOCS): A Novel Framework of Antioxidant Capacity Profiling Chemical Product and Process Modeling. ,vol. 9, pp. 25- 43 ,(2014) , 10.1515/CPPM-2013-0041
Andrew Anighoro, Jürgen Bajorath, Giulio Rastelli, Polypharmacology: Challenges and Opportunities in Drug Discovery Journal of Medicinal Chemistry. ,vol. 57, pp. 7874- 7887 ,(2014) , 10.1021/JM5006463
Michelle M. Feuereisen, Mariana Gamero Barraza, Benno F. Zimmermann, Andreas Schieber, Nadine Schulze-Kaysers, Pressurized liquid extraction of anthocyanins and biflavonoids from Schinus terebinthifolius Raddi: A multivariate optimization Food Chemistry. ,vol. 214, pp. 564- 571 ,(2017) , 10.1016/J.FOODCHEM.2016.07.002
B.V. Owoyele, S.B. Olaleye, E.A. Adewoye, S.A. Onasanwo, R.A. Elegbe, E.O. Farombi, Analgesic and anti-inflammatory effects of kaviiron (a Garcinia kola seed extract) African Journal of Biomedical Research. ,vol. 3, pp. 171- 174 ,(2000) , 10.4314/AJBR.V3I3
Stephen J. Pintauro, Dietary supplement use in the United States CRC Press. pp. 7- 18 ,(2018) , 10.1201/9780429442285-2
M. M. Iwu, Antihepatoxic constituents of Garcinia kola seeds. Cellular and Molecular Life Sciences. ,vol. 41, pp. 699- 700 ,(1985) , 10.1007/BF02007729
F. R. Irvine, Woody plants of Ghana. Woody plants of Ghana.. ,(1961)
Benetode Konziase, Protective activity of biflavanones from Garcinia kola against Plasmodium infection Journal of Ethnopharmacology. ,vol. 172, pp. 214- 218 ,(2015) , 10.1016/J.JEP.2015.06.038
Olayinka O Adegbehingbe, Saburi A Adesanya, Thomas O Idowu, Oluwakemi C Okimi, Oyesiku A Oyelami, Ezekiel O Iwalewa, Clinical effects of Garcinia kola in knee osteoarthritis Journal of Orthopaedic Surgery and Research. ,vol. 3, pp. 34- 34 ,(2008) , 10.1186/1749-799X-3-34