Cyclooxygenase-2 Gene Expression

摘要: Cyclooxygenases (COX) also known as prostaglandin (PG) synthases, are present in two forms, COX-1 and COX-2. Whereas is responsible for cytoprotective functions a number of organs, COX-2, which normally absent at basal levels, induced under certain conditions including pathophysiological states like acute inflammation, arthritis, well cancer cancer-related angiogenesis. Overexpression COX-2 enhances PGE2 synthesis, thereby resulting increased cellular proliferation, an important role the molecule progression. In addition, levels protect cells from deleterious effects ionization radiation (IR). expression tightly controlled normal conditions. At transcriptional level, gene by multiple elements 800-bp region proximal to transcription start site. Many factors bind these regulate transcription. Among them, key NF-kB b-catenin. Of these, b-catenin especially interesting because it can egulate both directly binding promoter comples with either TCF-4/LEF or p300, indirectly inducing PEA-3, subsequently binds its cognate element induce mRNA regulated post-transcriptional stability translation. This mediated AU-rich sequence located 3¢UTR mRNA. Multiple RNA proteins have been identified that sequences 3¢-UTR mediate this process. HuR, ubiquitously expressed protein, overexpressed colon other cells, increases translation contrast, CUGBP2 undergoing apoptosis inhibits Another protein hnRNPA1, whereas those inhibit TIA1, TTP, TIAR, AUF1.