Cyclooxygenase-1 and -2 in spinally projecting neurons are involved in CRF-induced sympathetic activation
作者： Naoko Yamaguchi , Shoshiro Okada
DOI: 10.1016/J.AUTNEU.2009.06.009
关键词:
摘要: Corticotropin-releasing factor (CRF) in the brain has been shown to stimulate sympathetic activity, leading elevations of blood pressure, heart rate and plasma catecholamine levels neuronal activation ganglia adrenal medulla. We previously reported that cyclooxygenase (COX), rate-limiting enzyme synthesis prostanoids, is involved centrally administered CRF-induced rats. Therefore, present study was designed reveal effect CRF (1.5 nmol/animal) on expression COX isozymes, COX-1 COX-2, spinally projecting neurons until 6 h after administration, using rats microinjected with a monosynaptic retrograde tracer into intermediolateral cell column thoracic spinal cord. Retrogradely labeled were detected paraventricular hypothalamic nucleus (PVN), locus coeruleus (LC), raphe pallidus rostral ventrolateral Centrally significantly increased number PVN expressing throughout experimental period those COX-2 during only late phase. also LC period. In other regions, administration had no COXs neurons. These results suggest play roles regulation
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