Stimulation of the activities of hepatic fatty acid oxidation enzymes by dietary fat rich in alpha-linolenic acid in rats.
作者： T Ide , M Murata , M Sugano
DOI: 10.1016/S0022-2275(20)37590-8
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摘要: The activities of hepatic fatty acid oxidation enzymes in rats fed perilla oil rich alpha-linolenic (alpha-18:3) were compared with those saturated fats or safflower (the mixture and olive oil, 94:8, w/w) containing the same amount polyunsaturated acids exclusively as linoleic (18:2). When diets 15% coconut, safflower, oils for 1 week, rate mitochondrial peroxisomal palmitoyl-CoA (16:0-CoA) liver homogenates was highest oil. Among palm, 2 weeks, rates oxidations 16:0-, 18:2-, alpha-18:3-CoAs alpha-18:3-CoA by both pathways higher than other acyl-CoAs all groups. Dietary relative to palm significantly increased carnitine palmitoyltransferase, acyl-CoA dehydrogenase, oxidase, 2,4-dienoyl-CoA reductase. substrate specificity palmitoyltransferase appeared be responsible differential acyl-CoAs. oxidase did not account preferential alpha-18:3 18:2. beta-oxidation 16:0- 18:2-CoAs also confirmed laboratory chow irrespective substrate/albumin ratios assay mixture. It suggested that specificities alterations pathway play a significant role regulation serum lipid concentrations diet alpha-18:3.
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