Putative Tumor Suppressor Genes EGR1 and BRSK1 Are Mutated in Gastric and Colorectal Cancers.

摘要: Objective: The transcription factor-encoding EGR1 and the kinase-encoding BRSK1 are considered putative tumor suppressor genes (TSGs). However, mutations that could inactivate their functions not reported in colorectal (CRC) gastric (GC) cancers. Methods: There mononucleotide repeats BRSK1, which be mutated cancers with defects mismatch repair, resulting microsatellite instability (MSI). We analyzed 124 CRCs 79 GCs for intratumoral heterogeneities (ITHs). Results: Twenty-one out of (26.6%) 5 34 (14.7%) carrying high MSI (MSI-H) exhibited frameshift mutations. we found no such stability. In addition, studied ITH these 16 cases observed 3 (18.8%) 2 (12.5%) cases, respectively. Conclusion: Our data this study reveal TSG carry mutational as well MSI-H CRC GC, together may features GC MSI-H. These results suggest might play a role tumorigenesis through inactivation GC.