Impaired production of naive T lymphocytes in human T-cell leukemia virus type I–infected individuals: its implications in the immunodeficient state

摘要: Opportunistic infections frequently occur in patients with adult T-cell leukemia (ATL) and human virus type I (HTLV-I) carriers. However, the underlying mechanisms of such remain unknown. To clarify mechanism immunodeficiency those infected HTLV-I, this study analyzed subsets HTLV-I carriers HTLV-I-associated myelopathy/tropical spastic paraparesis ATL using 3-color fluorescence CD62L CD45RA coexpression either CD4(+) or CD8(+) T cells. The number naive lymphocytes was markedly suppressed ATL, particularly acute form, compared uninfected control individuals. cells low HTLV-I-infected individuals under 50 years old individuals, whereas memory greater Although increase correlated provirus loads, no relationship found between counts loads. receptor rearrangement excision circles (TRECs), which are generated by DNA recombination during early lymphopoiesis, were quantified to evaluate thymic function TREC levels lower than In less 70 old, an Epstein-Barr peripheral blood mononuclear observed 6 16 (38%) examined, it detectable only 1 11 controls. These results suggested that due production thymus, might account for