Taste-immunosuppression engram: Reinforcement and extinction.

摘要: Several Pavlovian conditioning paradigms have documented the brain's abilities to sense immune-derived signals or immune status, associate them with concurrently relevant extereoceptive stimuli, and reinstate such responses on demand. Specifically, naturalistic relation of food ingestion its possible consequences facilitates taste-immune associations. Here we demonstrate that saccharin taste can be associated immunosuppressive agent cyclosporine A, associative learning is subject reinforcement. Furthermore, once consolidated, this saccharin-immunosuppression engram resistant extinction when avoidance behavior assessed. More importantly, more activated, either at association phases, pronounced conditioned immunosuppression.