Bilateral deep brain stimulation of the subthalamic nucleus increases pointing error during memory-guided sequential reaching

摘要: Deep brain stimulation of the subthalamic nucleus (STN DBS) significantly improves clinical motor symptoms, as well intensive aspects movement like velocity and amplitude in patients with Parkinson's disease (PD). However, effects bilateral STN DBS on integrative coordinative control are equivocal. The aim this study was to investigate using a memory-guided sequential reaching task. primary outcomes were eye finger end-point error. We expected that would increase velocity. More importantly, we hypothesized error not simply be result speed accuracy trade-off. Ten PD bilaterally implanted stimulators performed task under four stimulator conditions (DBS-OFF, DBS-LEFT, DBS-RIGHT, DBS-BILATERAL) over 4 days. DBS-BILATERAL increased compared DBS-OFF, DBS-RIGHT. It also DBS-OFF did change novel finding DBS-RIGHT even after adjusting for differences conclude may facilitate basal ganglia-cortical networks underlie velocity, but it disrupt selective certain such spatial accuracy.