Purging of bone marrow with a cocktail of monoclonal antibodies (VIB-pool) for autologous transplantation.
作者： F. Zintl , B. Reiners , H. Thränhardt , J. Hermann , D. Fuchs
DOI: 10.1007/978-3-642-72624-8_19
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摘要: Children with relapsed common acute lymphoblastic leukemia (ALL), B-non-Hodgkin lymphoma (B-NHL), and B-acute lymphocytic (B-ALL) have a very poor prognosis. If there is no HLA-identical donor, the patient should be considered for autologous bone marrow transplantation. Collected cleansed of contaminating tumor cells without destroying hemopoietic stem cells. We report here results our investigations cocktail three monoclonal antibodies (VIL-A 1, VIB-C 5, VIB-E 3 — VIB pool kindly given to us by Dr. Knapp Vienna) concerning in vitro cytotoxicity against ALL blast leukemic lines, lytic capacity rabbit human complement, cell toxicity, together findings ex vivo purging four children.
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