What defines success in pancreas and islet transplantation-insulin independence or prevention of hypoglycemia? A review.

摘要: Pancreas transplantation is considered to be the treatment of choice for selected uremic and diabetic patients, insurance coverage widely provided. In USA, islet an experimental procedure that awaits formal results ongoing phase III trials justify biologic licensure transition standard care. registry analyses focus on different functional endpoints: insulin independence (pancreas transplants) versus avoidance hypoglycemia (islet transplants). Although transplants have significantly improved, frequent use multiple donor organs, suboptimal yields, difficulties in monitoring successful engraftment or diagnosing rejection remain major barriers need overcome. pancreas transplantations are frequently competing procedures, they actually complementary options patients with type 1 diabetes mellitus. Because superior those transplants, a low surgical risk should undergo transplantation. Type 1 diabetics high (eg, serious comorbidities) Only integrated approach transplantation, tailored individual patient, will maximize benefit scarce resource. Both if successful, common represent only option date prevents long term.