Characterizing sudden death and dead-in-bed syndrome in Type 1 diabetes: analysis from two childhood-onset Type 1 diabetes registries.

摘要: Diabet. Med. 28, 293–300 (2011) Abstract Aims  Type 1 diabetes mellitus increases the risk for sudden unexplained death, generating concern that processes and/or treatments underlie these deaths. Young (< 50 years) and otherwise healthy patients who are found dead in bed have been classified as experiencing ‘dead-in-bed’ syndrome. Methods  We thus identified all unwitnessed deaths two related registries (the Children’s Hospital of Pittsburgh Allegheny County) yielding 1319 persons with childhood-onset (age < 18 years) diagnosed between 1965 1979. Cause death was determined by a Mortality Classification Committee (MCC) at least physician epidemiologists, based on certificate additional records surrounding death. Results  Of 329 participants had died, has so far reviewed assigned final cause to 255 (78%). Nineteen (8%) were (13 male) seven met dead-in-bed criteria. The adjudicated as: diabetic coma (n = 4), unknown (n = 2) cardiomyopathy (n = 1, autopsy). three individuals participated clinical study higher HbA1c, lower BMI daily insulin dose compared both those dying from other causes surviving. Conclusions  Sudden seems be increased 10-fold associated male sex, while high HbA1c low BMI. Although sample size is too small definitive conclusions, results suggest specific sex metabolic factors predispose death.