The Importance of Electric Field Distribution for Effective in Vivo Electroporation of Tissues

摘要: Cells exposed to short and intense electric pulses become permeable a number of various ionic molecules. This phenomenon was termed electroporation or electropermeabilization is widely used for in vitro drug delivery into the cells gene transfection. Tissues can also be permeabilized. These new approaches based on are cancer treatment, i.e., electrochemotherapy, vivo In thus gaining even wider interest. However, electrode geometry distribution were not yet adequately addressed. Most electrodes so far determined empirically. our study we 1) designed two sets that produce notably different field tumor, 2) qualitatively evaluated current density both by means magnetic resonance imaging, 3) three-dimensional finite element model calculate values sets, 4) demonstrated difference electrochemotherapy effectiveness mouse tumor between sets. The results clearly demonstrate numerical reliable very useful additional search would make general more efficient. Our shows better coverage tumors with sufficiently high necessary improved effective- ness electrochemotherapy.