Infection with Strongyloides venezuelensis Induces Transient Airway Eosinophilic Inflammation, an Increase in Immunoglobulin E, and Hyperresponsiveness in Rats

摘要: Infection by nematode parasites with a pulmonary migration in their life cycle and allergic asthma are two highly prevalent diseases humans; therefore, one may expect both occur concomitantly. There is predominant essential role of Th2 lymphocytes the mechanisms underlying control parasite elimination as well pathology observed asthmatic lung. The consequences such situations have been explored, controversial results, justifying development experimental models which relationship between airway inflammation helminth infection might be evaluated. present work describes inflammatory, humoral, functional changes that lung rats after single (subcutaneous inoculation 1,500 L3 larvae) or multiple (five weekly subcutaneous inoculations Strongyloides venezuelensis infections. results show S. larvae through lungs infected induces local eosinophilic process mostly focal parenchymal for time peribronchial inflammatory accompanied mucus hypersecretion, thickening bronchial epithelial muscle layers, increase immunoglobulin E concentrations peak 5 to 7 days resolved 12 immunopathologic coincides hyperresponsiveness (AHR), key alteration asthma. We propose this model ideal carry out further studies on immunoprotection against versus immunopathology inflammation.